Semaglutide Tirzepatide Mechanism GLP-1 only (single hormone) GLP-1 + GIP (dual hormone) Trial-average weight loss 13.7% of body weight (about 33.1 lbs) in SURMOUNT-5 20.2% of body weight (about 50.3 lbs) in SURMOUNT-5 Common side effects Nausea, constipation, reflux, usually early and fading Similar profile, sometimes stronger appetite suppression Optima pricing $249 for 10 weeks, all-inclusive $499 for 10 weeks, all-inclusive Best for Steady, proven weight loss at a lower price point The largest average reduction, if the cost fits your goals Both use the same active ingredients as the FDA-approved brand-name drugs, but Optima's compounded versions are prepared by licensed pharmacies and are not themselves FDA-approved
That means you could be looking at a long-term financial commitment
Reimbursement and coverage policies
GLP-1 RAs have demonstrated favorable trends toward improving endocrine and metabolic outcomes, including reductions in ALT, AST, HbA1c, body weight, BMI, LFC, and IHA
