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Nature Communications , 11 (1)

Peptides and steroids are not interchangeable

Some antidiabetic drugs, like pioglitazone, metformin, and glucagonlike peptide1 (GLP1) agonists, may also have antiinflammatory effects

Given that several further dual agonists are coming closer to becoming licenced, such as mazdutide and survodutide, with many more in development [15], combining licenced dual agonists with developing mono-agonists may be a faster way to develop effective treatments achieving triple agonism