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Considering that Mg 2+ has a strong inhibitory effect on RyR [81], these findings were challenged [82], arguing that Mg 2+ levels were abnormally low in previous studies and they demonstrated that in physiological levels of Mg 2+ , carnosine does not play a role in stimulating the RyRs

Conversely, cortisol deficiency (Addison's disease or secondary adrenal insufficiency) presents with fatigue, weight loss, hypotension, and potentially life-threatening adrenal crisis

Substance use as a risk factor for bipolar disorder: a systematic review