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Together with their antioxidant roles against reactive oxygen species (ROS) and reactive nitrogen species (RNS), NAC and HPN-07whose structural analog is -phenyl-N-tert-butylnitrone (PBN)have each been reported to promote neurogenesis through proposed mechanisms involving the activation of the Rasextracellular signal-regulated kinase (ERK) and protein kinase C (PKC) pathways 30,31,32

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3,4 Importantly, interindividual responses may vary due to the oral nitrate-reducing microbiome, as antibiotics or antibacterial mouthwash can inhibit the conversion of nitrate to nitrite