613,614 Astrocytes in AD animal models, as well as astrocytes differentiated from stem cells isolated from AD patients, are characterised by decreased energy metabolism, decreased glucose uptake and glucose consumption
Although initially there were some doubts concerning this conclusion, mainly due to a lack of experimental support from animal studies and insufficient epidemiological evidence, but now numerous clinical experimental studies during the last decade have vindicated the IARC conclusion
10.1038/s41419-020-02939-3 Cell Death Dis
For others, it can take longer, especially if symptoms have been present for months or if there are multiple contributing factors (iron, vitamin D, thyroid issues, sleep, stress, etc.)