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In this context, a phase 2 trial involving patients with obesity and T2DM reported noteworthy results

Fat oxidation is the process by which stored fat is broken down and used for energy

While Ser2 of oxyntomodulin and Ala8 of GLP-1 both interacted with TM7 residues, these interactions were stronger with oxyntomodulin due to a persistent hydrogen bond between Ser2 and E387 7.42 and transient hydrogen bonds and van der Waals contacts with K383 7.38 , D372 ECL3 and L384 7.39 (Supplementary Table 3)

This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established