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However, AD pathology extends beyond amyloid and tau, encompassing a multifaceted array of pathophysiological mechanisms, including chronic neuroinflammation, oxidative stress, mitochondrial dysfunction, impaired proteostasis (the homeostasis of protein folding, stability, and degradation), calcium dysregulation, excitotoxicity, and breakdown of the blood-brain barrier (BBB) [16, 17]
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It is controversial whether a fusion is actually necessary in the case of a stable degenerative scoliosis with stenosis but the accepted approach is to perform a fusion If an instrumented fusion is considered it would require at least a T11-pelvis fusion
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