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Although NADPH is required for the metabolism and eventual detoxification and excretion of Dox, the immediate products of NADPH-fuelled Dox metabolism include doxorubicinol (Fig

J Affect Disord (2013) 145(2):16571

Clinically isolated syndrome (CIS) A first attack of neurological disability with accompanying white matter lesion(s) on imaging, that may or may not develop into MS characterized by recurrent lesions distributed in space and time