anhedonia semaglutide TheCut just released an article on one of the long-term side effects of GLP-1s Can GLP-1 Medications Cause Anhedonia?

Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors

Full cumulative benefit: 3-6 months of consistent daily use

The certainty of evidence, assessed using GRADE methodology, ranged from high for colorectal cancer to moderate for liver cancer to low for pancreatic cancer, reflecting variations in trial consistency and event rates ( Since most studies focused on liraglutide and semaglutide, the outcomes are most relevant to these drugs, even though the pooled analysis considered all data from the GLP-1 RA class

Also, had some questions and the company is very responsive