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(2008) www.sciencedaily.com From the article: Low-trauma fractures occurred in 113 men during follow-up with the risk of fracture significantly higher in those with low testosterone levels

Treatment of wild mice with PCPA or TPH1 knockout produced a significant reduction of GSH and GSH-px levels in liver after APAP administration when compared with the WT or KO+5-HTP groups (Figure 4D)

While these signs don't always correlate with chemical degradation, they can indicate storage problems that warrant investigation