glp 1 long term risks Thoughts on GLP-1 use? 🤔 this is not medical advice and you can listen to the full episode now. Link in bio! Long-term cancer risk in users

GLP-1 Medications Effective while taking them Can require lifelong use Weight regain common after stopping Real-world adherence varies Cost can be substantial over time Bariatric Surgery Proven long-term weight loss and remission of conditions like diabetes and sleep apnea More durable than GLP-1s alone Supported by decades of data and clinical outcomes Often covered by insurance Includes lifetime follow-up care at Grand Health Partners Studies show bariatric surgery delivers significantly greater long-term results compared to GLP-1 medications

Efficacy Characteristics: Clinical trials show that its efficacy peaks about 4 hours after injection, can quickly stimulate sexual desire, and is non-addictive

The reaction was terminated by the addition of NEM to a final concentration of 50 mM

GLP-1R is expressed in dorsal root ganglion (DRG) neurons 40 and could explain the potential direct effect on pain in OA since DRG neuron endings are present in the synovium 41