Many clients notice deeper sleep within 2 weeks
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The genetic correlates relate primarily to variants in the genes coding for transporters controlling plasma UA, yet such presumed functional variants will also influence, through the same proteins, the transport of UA into the brain and subsequently into neurons and glia, as described below
Qualifying Comorbidities FDA labeling and clinical guidelines commonly recognize: Hypertension (blood pressure 130/80 or taking antihypertensive medication) Type 2 diabetes (HbA1c 6.5% or on glucose-lowering medication) Prediabetes (HbA1c 5.7-6.4% or impaired fasting glucose) Dyslipidemia (elevated LDL, low HDL, or elevated triglycerides) Obstructive sleep apnea (diagnosed via sleep study) Cardiovascular disease (prior MI, stroke, coronary artery disease) Non-alcoholic fatty liver disease / MASLD Polycystic ovary syndrome (PCOS) with metabolic features Osteoarthritis weight-bearing joints Insurance formularies may be stricter some require objective documentation (lab values, sleep study reports) rather than self-report
