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The basal insulin/DPP-4 inhibitor combination is a practical and a less complicated treatment option without the need for multiple injections during the day, less need for glucose self-measurements and dose adjustments for insulin ( The treatment algorithm recommended by ADA and EASD is summarized in Figure 3 ( Figure 3 Conclusions DPP-4 inhibitors are important oral antidiabetic agents that are placed as second-line therapy after metformin failure as insulinotropic agents that have no intrinsic hypoglycaemia risk and are body weight neutral

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Evidence for defective mesolimbic dopamine exocytosis in obesity-prone rats