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STABLE GASTRIC PENTADECAPEPTIDE BPC 157 HEALS CYSTEAMINE-COLITIS AND COLON-COLON-ANASTOMOSIS AND COUNTERACTS CUPRIZONE BRAIN INJURIES AND MOTOR DISABILITY 2Department of Pathology, Medical Faculty, University of Zagreb, Zagreb, Croatia INTRODUCTION Several important findings recently appear in inflammatory bowel disease (IBD) and ulcerative colitis (1, 2) in particular, alterations of the brain-gut interactions ("brain-gut axis") (3) while stable gastric pentadecapeptide BPC 157 particular effects on nitric oxide (NO)-system (4), nonsteroidal anti-inflammatory drugs (NSAIDs)-toxicity, peripheral and central (5), gastrointestinal tract (6, 7) and wound-healing, and blood vessels (8), were recently reviewed

[16] [17] [18] It was also established that GHK-Cu stimulates both the synthesis of metalloproteinases, the enzymes which break down dermal proteins, and their inhibitors (anti-proteases)