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Moreover, newer GLP-1 RAs and the long half-life of dual agonists (up to 7 days for Semaglutide) give rise to longer preoperative fasting period requirements and concerns of perioperative management of patients, even in case of treatment interruption [15,16,17]

According to the Phase 2 trial published in the New England Journal of Medicine , retatrutide achieved weight reductions up to 24.2% at 48 weeks , with projections nearing or exceeding 25% at full duration (Coskun et al., 2023)

Weve known that for many years as well

Ozempic (semaglutide) slows gastric emptying and reduces gastrointestinal motility as part of its mechanism of action, which can decrease bowel movement frequency and cause constipation in 1-10% of users