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Specifically, patients were randomized in an open-label fashion to receive either: (i) PIO 30 mg/day for 2 weeks followed by PIO 45 mg/day for 50 weeks ( n = 10) or (ii) EXE 5 g twice daily and PIO 30 mg/day for 2 weeks followed by EXE 10 g twice daily and PIO 45 mg/day for 50 weeks ( n = 11)

While the thigh is a common and easy-to-reach site for semaglutide injections, you can also inject it into the abdomen or upper arm

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Across the trials, when people stop the medication, the weight tends to come back, on the order of two-thirds of what was lost within a year