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Together, these findings highlight that both pharmacological antidepressants and bioactive dietary compounds like flavonoids can shift KP metabolism toward neuroprotective pathways, offering potential avenues to alleviate inflammation-driven depressive pathology

Participants analyzed for efficacy (Rim=286, Pbo=284) had documented failure to 2 triptans with 1 reason due to prior intolerance (30.5%) or lack of efficacy (84.9%)

Proinflammatory cytokines such as Tumor Necrosis Factor (TNF)-, interleukin (IL)-1 or IL-18 induce the endocytosis of epithelial apical junctional proteins [120], promoting an increment in intestinal permeability [121]

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