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We assessed the methodological quality of the included articles according to the Cochrane risk of bias criteria [11]

Confirm diagnostic and CDC updates before use for STDs

C.SchneiderE.et al

Oxidative DNA damage can lead to global hypomethylation or locus-specific changes [49,50,51,52,53], while histone modification, such as reduced H3K4 methylation and altered acetylation of H3 and H4 residues affect the expression of genes controlling antioxidant defense and mitochondrial function [54,55,56,57,58,59]