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Moreover, meta-analyses and real-world evidence confirm that these benefits extend beyond clinical trials, underscoring their relevance for policymakers and endocrinologists aiming to optimize metabolic disease management
Antiestrogenic action Among the oncostatic effects of melatonin, antiestrogenic actions are instrumental, especially relevant in hormone-dependent tumors, such as breast, prostate, and ovarian cancer [49]
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Importantly, not all variants confer increased risk: loss of function variants in HSD17B13, a lipid droplet-associated protein in hepatocytes, have been consistently associated with reduced hepatic inflammation and a lower risk of fibrosis and advanced liver disease [16]
