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4.1.2 Clinical applications and implications This meta-analysis brings to light various clinically relevant aspects that must be considered from a public health perspective: Reassurance in Clinical Decision-Making As part of our results, it is evident that GLP-1 RAs do not increase the risk for gastrointestinal cancers and may even have protective effects for colorectal and liver cancers

Unlike testosterone-based approaches, PT-141 acts centrally on melanocortin receptors (MC3R, MC4R) in the brain, influencing desire through dopaminergic pathways rather than peripheral blood flow

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