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Considering Danish costs of medications, diabetes consumables, and treatment of diabetes-associated complications, modelling all four trials over a 40-year horizon, these analyses indicated that treatment with either oral or subcutaneous semaglutide (a GPL-1RA) was likely to increase both costs and health benefits relative to empagliflozin, canagliflozin (SGLT-2is), and sitagliptin (DDP-4i) for treatment of patients with type 2 diabetes that is not adequately controlled with metformin (with or without sulfonylurea) in Denmark