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Its function is unknown, but it may play a role in maintaining the structure or pH of this environment.[84] Murine models with variants in this gene had significantly decreased melanin production compared with normal controls.[85] In one international study of individuals with albinism, biallelic variants in OCA2 were found in 17% of participants.[86] Genetic variants in SLC45A2 ( MATP associated with OCA4), SLC24A5 (associated with OCA6), and TYRP1 (tyrosinase-related protein 1 associated with OCA3) are associated with less common types of oculocutaneous albinism

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Under the stimulation of growth factors, PI3Ks are recruited onto the plasma membrane to catalyze the phosphorylation of the 3-hydroxy group of PIP2 to generate PIP3, which then acts as the second messenger, recruiting PDK1 and AKT proteins onto the plasma membrane to partially activate AKT by PDK1

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