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Conflict of interest Authors CD, VG, PK, SP, DN, MA, EU, TS, and VJ were employed by Capsugel France SAS

The more heavily you fast, the more the AgRP neurons dominate, leading you to overeat

This proposed mechanism has been directly validated in animal models where the surgically severed vagus nerve attenuated anxiety- and depression-like behaviors in mice after oral antibiotic administration, providing direct evidence for neuropsychiatric effects induced by antibiotics through the gutbrain axis (Joo et al., 2023)