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Mechanisms of ROS production In addition to mitochondrial sources, ROS generation involves various enzymatic pathways: transmembrane electron transfer mediated by NADPH oxidase (NOX), substrate oxidation catalysed by xanthine oxidoreductase (XOR), and byproducts from lipoxygenase (LOXs) and cyclooxygenase (COX) during arachidonic acid metabolism [11]

Heavy metals can also replace metallic cofactors in key enzymes, perturbing metabolic reactions and inducing excessive ROS production, thereby amplifying oxidative stress (Fig

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Effects of acute N-acetylcysteine challenge on cortical glutathione and glutamate in schizophrenia: A pilot in vivo proton magnetic resonance spectroscopy study