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Additionally, research should target understudied patient populations such as early-onset neurodegenerative patients, individuals with genetic predispositions, and populations with complex comorbidities

Mechanistically, cancer cells capable of inducing cancer cachexia are secreting IL-6, which subsequently induces autophagy in differentiated muscle cells via IL-6 signaling and therefore might be relevant for the characteristic muscle and weight loss during cancer cachexia (276)

Vigneri PG, Tirro E, Pennisi MS, Massimino M, Stella S, Romano C, et al

In 2024, the Biden administration proposed a rulethat would have aligned coverage policy to reflect the prevailing medical consensus that obesity is a chronic disease, thereby rendering treatment of obesity as a medically necessary service under Medicare