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The most robust evidence to date comes from the phase 2 randomised controlled trial (Jastreboff et al., NEJM , 2023)

Such comparisons have the potential to reveal direct genetic underpinnings and cellular mechanisms of symbiosis, which are challenging to disentangle in systems that exhibit natural variation in symbiotic densities

Clinical trial data for semaglutide points to average losses of around 15% of body weight over 68 weeks when combined with diet and lifestyle changes

322 HFD may also enhance neuroinflammation by increasing circulating free fatty acids and cytokines, which may lead to cognitive impairment