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Gastroenterol 58:96107 Herrmann-Rinke C, Vge A, Hess M, Gke B (1995) Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides
Injectable GLP-1s typically reach therapeutic levels faster in the bloodstream and maintain consistent dosing without breakfast-related variables
The research group led by Kojima and Kangawa was inspired by the fact that motilin, the endogenous ligand for GPR38 (the motilin receptor), which shares high amino acid homology with GHS-R1a, is secreted from the gastrointestinal tract
Reported effects include alterations (either increases or decreases) in cAMP levels, increases in K + -conductance, and decreases in Ca 2+ -conductance
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