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This antioxidant has been associated with a delay in the clinical onset of the disease (Table 1) in transgenic mice that express mutant copies of the gene encoding SOD1 (an animal model of ALS) (Gurney et al., 1996)

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Elsevier, Amsterdam, The Netherlands, pp 639667 Baker AF, Adab KN, Raghunand N, Chow H, Stratton SP, Squire SW, Boice M, Pestano LA, Kirkpatrick DL, Dragovich T (2013) A phase IB trial of 24-hour intravenous PX-12, a thioredoxin-1 inhibitor, in patients with advanced gastrointestinal cancers

Glutathione metabolism is an important pathway in IAV infection, regulating the progression of the infection Based on the microarray dataset GSE101702, which includes patients with common IAV infections at different ages and severe infections, combined with the results of immune-related changes in the internal environment caused by IAV infection, we hypothesised whether this change is related to the severity of IAV infection or the age of the infected patient