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EN is a severe hypersensitivity reaction with mucocutaneous detachment and high mortality, and is generally secondary to treatment with drugs such as allopurinol, anticonvulsants, anti-inflammatories, penicillins, or sulfa drugs (Table 1)

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CXCR4 up-regulation by imatinib mesylate induces CML cell migration to bone marrow stroma and promotes survival of chemoresisitance quiescent CML cells