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The moment the degree of those proteins decreases, wrinkles and fine lines have a tendency to appear

[168] [169] In June 2025, the European Medicines Agency recommended that the product information for semaglutide medicines be updated to include non-arteritic anterior ischemic optic neuropathy (NAION) as a very rare side effect, [170] while the World Health Organization concluded that the risk management plan for semaglutide should be revised to include NAION as a potential risk

That means sourcing, dosing, and monitoring are all the responsibility of the owner and vet

The data are included in the Supplementary Information