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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

That involves comparing the performance of a drug with that of a placebo

However, consumers should exercise caution and consult healthcare providers before using such supplements, as their safety and efficacy might not be well-established