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however, some potential scenarios where it might be considered (only within an individualised plan agreed with a clinician) include: As an adjunct to lifestyle measures in individuals with non-diabetic hyperglycaemia (prediabetes) who wish to try additional interventions In people with type 2 diabetes who cannot tolerate metformin and are exploring complementary approaches alongside other prescribed medications As part of a holistic approach in individuals already achieving good glycaemic control who wish to explore additional metabolic support Important caveats : Berberine should never replace prescribed diabetes medications without explicit guidance from your diabetes care team Berberine should not be used for type 1 diabetes, diabetic ketoacidosis, during pregnancy or breastfeeding Self-management with supplements can be risky

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Jennifer Sargent was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team