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Slow titration is the primary mitigation

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[5] [6] References [edit] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116157 Ensembl, May 2017 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028597 Ensembl, May 2017 "Human PubMed Reference:"

Eventually, this leads to the production of lipid aldehydes, which initiate ROS-mediated peroxidation and subsequently trigger apoptosis ( Figure 2