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Patient Comfort : For routes of administration such as ophthalmic, nasal, or injectable preparations, maintaining a pH close to physiological conditions (e.g., pH 7.4) is essential to minimize irritation and enhance patient comfort

Visceral adiposity index, a surrogate parameter of adipose tissue dysfunction associated with cardiometabolic risk in healthy subjects, significantly decreased after CAB long-term therapy in hyperprolactinemic patients ( Diverse first-line therapeutic approaches seem to differently affect lipid metabolism since a significant reduction in triglycerides has been found in patients undergone pituitary surgery whereas a significant decrease in total cholesterol has been shown after DAs therapy ( Therefore, the increased levels of PRL result in an impairment of apolipoprotein biosynthesis, increased total, LDL-cholesterol and triglycerides, and decreased HDL-cholesterol together with higher body fat percentages in hyperprolactinemic patients as compared to controls

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