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En cirrosis compensada derivada de EHMET, en un primer trabajo la semaglutida a dosis de 2,4mg no mejor significativamente la fibrosis ni logr la resolucin de la NASH en comparacin con el placebo en un ensayo realizado en 71 pacientes con un IMC medio de 34,9kg/m2 (53 con DM2)

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3.4.3 Exploratory non-pharmacological approaches Non-pharmacological approaches serve as essential adjuncts for hyperuricemia management, particularly in asymptomatic individuals (Paul et al., 2017

Consistent with the observed trends, melatonin demonstrated comparatively stronger efficacy, particularly in preserving the follicular reserve, enhancing AMH expression, and reducing inflammatory markers