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The review further examines safety and tolerability data reported across these trials, focusing particularly on gastrointestinal side effects and emerging considerations such as reductions in lean body mass accompanying substantial weight loss

[DOI] [PMC free article] [PubMed] [Google Scholar] Pagano C, Calarco P, Ceccarini MR et al

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2.3 Overproduction and purification of MSA-DH and MDH MSA-DH fused to an N-terminal His-thioredoxin tag or MDH fused to an N-terminal His-tag was overproduced in E