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Validating robust, non-invasive biomarkers (e.g., circulating lipid peroxide metabolites, urine exosomal ferroptosis regulators, or TME-derived immune cell ferroptosis signatures) is urgently needed to guide clinical trial design and patient stratification

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The peptides role in enhancing interactions with dopaminergic, serotonergic, and opioid systems also suggests potential applications in treating neurodegenerative disorders such as Parkinsons disease, where these neurotransmitter systems are often compromised

The hypertonicity is reported to increase the number of BGT1 in the basolateral membrane (Schwab et al., 2006)