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Key Takeaways Tesamorelin is FDA-approved: it is the only GHRH analog with an approved indication for visceral fat reduction, giving it one of the best-documented clinical safety profiles among peptides

The study did not address effects of a selective GLP-2 receptor agonist, which makes it presently unresolved to what extent stimulated GLP-2 receptor function may have contributed to the gut microbiome changes following GUB09-145 treatment

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Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, et al