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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing

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The GLP-1 RA monitoring report describes more detailed information about the overall population of patients being prescribed these medications (including demographics and comorbidities), and the proportion and characteristics of patients who filled a GLP-1 RA prescription over time using dispenses