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Current clinical evidence suggests that semaglutide does not directly damage kidneys, but individual kidney function status determines whether dose modifications are necessary

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This makes Semaglutide the foundational reference molecule for GLP-1 biology, while Retatrutide represents the next generation of multi-receptor metabolic research

PMOS: GLP-1 medications are not licensed specifically for PMOS (formally known as Polycystic Ovarian Syndrome or PCOS for short) in the UK, but if you suffer from PMOS and also meet the BMI criteria, you can get them prescribed for weight management