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Intra-islet glucagon, acting through the beta cell GLP-1R and glucagon receptors, may also contribute to the incretin effect, perhaps reconciling findings of low circulating levels of GLP-1 yet substantial meal-stimulated GLP-1R-dependent potentiation of insulin secretion [45, 46]

Maintaining ROS homeostasis is essential for cell survival [32]

doi: 10.3389/fmed.2023.1191113 5 YangYGuXZhuLChengYLuHGuanZet al

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