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Although the signal for its intended outcomes was positive, public fervor for the drug diminished when the FDA ultimately rejected approval in the United States because of an increased risk of adverse psychiatric outcomes in the treatment group, including two deaths by suicide

Chinese manufacturers (WuXi TIDES, GL Biochem, Hybio) are the primary drivers of volume growth at lower ASPs, while Western manufacturers (Bachem, CordenPharma) are defending margins through quality premium, regulatory compliance, and complex molecule specialisation

In contrast, COX-2 overexpression can reduce IEC apoptosis induced by Giardia

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