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A recent meta-analysis of 12 observational studies found that higher dietary intake of vitamin B 12 was associated with a 23% lower risk of depression compared to lower intakes, but stratifying the data revealed a significant protective association in females, not in males (99)

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identified NGF and BDNF as potential mediators released by the degenerated NP cells that could be potentially exploited to block neurite ingrowth or modulate sensitization from a painful IVD