Individualized early goal-directed therapy in systemic inflammation: is full utilization of preload reserve the optimal strategy
N Engl J Med 314(23):14941497 Rocha JF, Vaz-Da-Silva M, Nunes T, Igreja B, Loureiro AI, Bonifcio MJ, Wright LC, Falco A, Almeida L, Soares-Da-Silva P (2012) Single-dose tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5453), a new dopamine -hydroxylase inhibitor, in healthy subjects
The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier
Researchers have proposed several mechanisms, including direct effects on gene transcription factors and indirect influences through cellular signaling cascades that regulate telomerase activity