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Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that may include a strong desire to take the drug, difficulties in controlling drug use (e.g., continuing drug use despite harmful consequences, giving a higher priority to drug use than other activities and obligations), and possible tolerance or physical dependence

Additionally, AC is chemically stable at acidic pH (pH 3) for up to 24 h in human intestinal cell lines, though, at neutral pH (pH 7), AC undergoes significant transformation (up to 62.4%) into isoverbascoside or other oxidative products (Xiao et al

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