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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction

A recent study showed that long-term duloxetine use could cause significant cardiovascular problems in older individuals (aged 7079 years), particularly those who already have cardiovascular disease [125]