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How Long Will Reduced Appetite Last While on Treatment While you use tirzepatide at the prescribed dose and maintain adherence, appetite suppression typically continues, and clinical studies show sustained benefits over long follow-up periods when combined with lifestyle changes

Abdominal distension, or swelling Abdominal pain Burping (eructation) Constipation Diarrhea Dizziness Dyspepsia, or upset stomach Fatigue Gas (flatulence) Gastroenteritis Gastroesophageal reflux disease (GERD) Hair loss Headache Heartburn Hypoglycemia Nausea Vomiting These side effects may appear mild at first, but they can escalate in severity or because of symptoms of more serious side effects

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About the study Researchers conducted a retrospective cohort study using de-identified electronic health records from the TriNetX United States Collaborative Network between January 2020 and November 2025