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Importantly, P5-induced cAMP production was inhibited by the selective GLP-1R antagonist Ex 939 in a concentration-dependent manner (Supplementary Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Sisley S, Gutierrez-aguilar R, Scott M, Alessio DAD, Sandoval DA, Seeley RJ

This is important because it indicates that any increase in systemic GLP-1 levels (for example through medication) could potentially influence the amount that reaches the joint. Tue Wenzel Kragstrup, MD, PhD The next step (in this research) is to find out whether GLP-1-based drugs reach the joints in high enough concentrations to have biological effects there, Kragstrup continued