Key Findings: Most common: Nausea (43%), diarrhea (33%), vomiting (21%) Unique to retatrutide: Dysesthesia (20.9% @ 12mg in TRIUMPH-4, 8.8% @ 9mg) Discontinuation rate: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 (general obesity population) compared to semaglutide 6.9%, tirzepatide 6.2% Good news: Most side effects peak during dose escalation and improve significantly after week 16 Management: Slow titration, dietary modifications, and proper timing dramatically reduce severity Understanding the Three Categories of Side Effects 1
These medications work by simulating the glucagon-like peptide-1 hormone, thereby reducing appetite and slowing down gastric emptying
The condition involves inflammation and micro-tearing of the plantar fascia, a thick band of connective tissue that runs along the bottom of your foot from the heel bone to the toes
This muscle deterioration can lead to increased thoracic kyphosis (rounded upper back), forward head posture, and tension headaches
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