family history, physical inactivity, high-risk ethnicity, poor diet, hypertension, dyslipidemia, PCOS, prior gestational diabetes, prediabetes, or cardiovascular disease All adults aged 45 or older, regardless of weight Children aged 10 or older with overweight or obesity and two or more risk factors, screened at puberty onset Pregnant individuals: gestational diabetes screening at 2428 weeks New in ADA 2026 Screen individuals initiating immune checkpoint inhibitors, PI3K inhibitors, mTOR inhibitors, or high-dose glucocorticoids, a significant new addition for oncology and transplant patients
They usually contain ingredients such as caffeine, citrulline, creatine, and beta-alanine
Rudin CM, Yang Z, Schumaker LM, VanderWeele DJ, Newkirk K, Egorin MJ, Zuhowski EG, Cullen KJ: Inhibition of glutathione synthesis reverses Bcl-2-mediated cisplatin resistance
Differentiation amongst these agents is important, and there are several factors that will make assets from smaller companies attractive: 1) oral and infrequent dosing regimens, 2) ability to improve cardiometabolic outcomes along with weight loss, and 3) reduced GI side effects
